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Sodium Cyanoborohydride CAS 25895-60-7

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Sodium Cyanoborohydride CAS 25895-60-7 Basic Parameter

Product Name:Sodium cyanoborohydride
CAS NO:25895-60-7
Molecular Formula:CH3BNNa
Molecular Weight:62.84
Melting Point:>242 °C (dec.) (lit.)
Boiling Point:307°C
Density:1.083 g/mL at 25 °C
Appearance:White powder
Storage:Store under dry nitrogen or argon atmosphere.
Stability:Avoid contact with oxides, acids, moisture/humidity

Sodium Cyanoborohydride CAS 25895-60-7 Picture

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What is sodium cyanoborohydride CAS 25895-60-7 used for?

As a mild reducing agent, it is used to convert imines to amines. It is especially favored for reductive aminations, wherein aldehydes or ketones are treated with an amine in the presence of this reagent: R 2CO + R’−NH 2 + Na[BH 3(CN)] + CH 3OH → R 2CH−NH−R’ + “Na[BH 2(CN)(OCH 3)]” +H 2O.

What does sodium cyanoborohydride reduce?

One common reducing agent for this purposes is sodium cyanoborohydride (NaBH3CN) which can selectively reduce imines in the presence of aldehydes. Many other reducing agents (NaBH4, NaBH(OAc)3, etc.) can be used as well.

What is the difference between NaBH4 and NaBH3CN?

Sodium cyanoborohydride (NaBH3CN) is a mild reducing agent that is commonly used in reductive aminations. The presence of the electron-withdrawing cyano (CN) group makes it less reactive than sodium borohydride (NaBH4).

What is an alternative to sodium cyanoborohydride?

Pyridine Borane as Alternative Reducing Agent to Sodium Cyanoborohydride for the PEGylation of L-asparaginase.

What is the advantage of sodium cyanoborohydride over sodium borohydride?

The cyanoborohydride offers five times milder reduction compared to borohydride in the reductive amination process, reducing the Schiff’s bases, but not the aldehydes2. The reductive amination process is pH-dependent, being more efficient in acidic conditions, especially at high pH.


Powder& Solid: The bulk powder is provided with double-layer aluminum thin bag odor-proof packaging and the small goods are replaced with plant extract animal food packaging bags
Liquid& Oil: The liquid is changed to a common product name in a sealed package, and there is a blister to prevent leakage

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