Pregabalin CAS 148553-50-8 Lyrica

Pregabalin CAS 148553-50-8, sold under the brand name Lyrica among others, is an anticonvulsant, analgesic, and anxiolytic amino acid medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, opioid withdrawal, and generalized anxiety disorder (GAD). Pregabalin also has antiallodynic properties. Its use in epilepsy is as an add-on therapy for partial seizures. It is a gabapentinoid medication (GABA analogue) which are drugs that are derivatives of γ-aminobutyric acid (GABA), an inhibitory neurotransmitter. Pregabalin acts by inhibiting certain calcium channels. When used before surgery, it reduces pain but results in greater sedation and visual disturbances. It is taken by mouth.

Pregabalin CAS 148553-50-8 Product Information

Lyrica Details

Pregabalin Uses

Seizures

For drug-resistant focal epilepsy, pregabalin is useful as an add-on therapy to other treatments. Its use alone is less effective than some other seizure medications. It is unclear how it compares to gabapentin for this use.

Neuropathic pain

The European Federation of Neurological Societies recommends pregabalin as a first line agent for the treatment of pain associated with diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain. A minority obtain substantial benefit, and a larger number obtain moderate benefit. It is given equal weight as gabapentin and tricyclic antidepressants as a first-line agent, however the latter are less expensive as of 2010. Pregabalin is as effective at relieving pain as duloxetine and amitriptyline. Combination treatment of pregabalin and amitriptyline or duloxetine offers additional pain relief for people whose pain is not adequately controlled with one medication, and is safe.

Anxiety disorders

Pregabalin is effective for treatment of generalized anxiety disorder. It is also effective for the short- and long-term treatment of social anxiety disorder and in reducing preoperative anxiety. However, there is concern regarding pregabalin’s off-label use due to the lack of strong scientific evidence for its efficacy in multiple conditions and its proven side effects.

Generalized anxiety disorder

Pregabalin has anxiolytic effects similar to benzodiazepines with less risk of dependence. The effects of pregabalin appear within one week of use, and are similar in effectiveness to lorazepam, alprazolam, and venlafaxine, but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for psychosomatic anxiety symptoms. Long-term trials have shown continued effectiveness without the development of tolerance, and, in addition, unlike benzodiazepines, it has a beneficial effect on sleep and sleep architecture, characterized by the enhancement of slow-wave sleep. It produces less severe cognitive and psychomotor impairment compared to benzodiazepines.

It is important to note that the use of pregabalin for off-label indications should be discussed with a healthcare professional, who can evaluate the potential benefits and risks based on an individual’s specific circumstances.

Always follow your healthcare provider’s instructions regarding the use of pregabalin and do not adjust the dosage or discontinue the medication without consulting them first.

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